RAS Mutations in Thyroid Cancer
نویسندگان
چکیده
منابع مشابه
Diagnostic Value of RAS Mutations in Indeterminate Thyroid Nodules.
Objectives To determine the diagnostic value of HRAS, KRAS, and NRAS mutations in fine-needle aspiration biopsies of thyroid nodules that are nondiagnostic on cytology. Data Sources PubMed, Scopus, Embase, CINAHL. Review Methods Two authors independently searched the data sources. To be included, studies reported the RAS mutational status and postoperative histopathologic diagnosis of nodules t...
متن کاملRoles of RAS and BRAF mutations in thyroid carcinogenesis.
Papillary carcinoma and follicular carcinoma are types of differentiated thyroid carcinomas, develop from the same thyroid follicular epithelial cells and show distinct biological behavior. Although several studies have demonstrated differences in the biological characteristics of these carcinomas, little is known about the genetic backgrounds that underlie these differences. The clarification ...
متن کاملRole of BRAF and RAS Mutations in Extrathyroidal Extension in Papillary Thyroid Cancer.
BACKGROUND/AIM Extrathyroidal extension (ETE) indicates the invasiveness of primary thyroid tumor into the adjacent tissue, and its importance as a prognostic factor overrides tumor size in classifying the cancer stage. The aim of this study was to determine the molecular basis of ETE in papillary thyroid carcinomas (PTCs). MATERIALS AND METHODS We systematically defined genes and pathways re...
متن کاملClinical utility of RAS mutations in thyroid cancer: a blurred picture now emerging clearer.
RAS mutations play an important role in thyroid tumorigenesis. Considerable effort has been made in the last decade to apply RAS mutations as molecular markers to the clinical management of thyroid nodules and thyroid cancer. Yet, for the low diagnostic sensitivities and specificities of RAS mutations, when used alone, and for their uncertain role in the clinical outcomes of thyroid cancer, it ...
متن کاملTERT promoter mutations and their correlation with BRAF and RAS mutations in a consecutive cohort of 145 thyroid cancer cases
Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy and accounts for ~80% of thyroid carcinomas in adults and 90% in children. Risk stratification is important for identifying patients at higher risk and, for this reason, recent advances in molecular genetics of thyroid cancer can be applied to provide novel biomarkers useful in understanding tumor behavior. B-Raf ...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 2013
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.2013-0072